Non sedating antidepressants

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Celexa (Citalopram) licensed indications: In January 2003, Prozac (fluoxetine) was approved by the FDA for the treatment of depression and OCD in children and adolescents who are 7 to 17 years of age.Zoloft (Sertraline) licensed indications: Clinical trials comparing one SSRI with another indicate that drugs in this class are equally efficacious.SSRIs are called selective because they seem to affect serotonin significantly more than other neurotransmitters.Thus, the medications work by allowing the body to make the best use of the reduced amounts of serotonin that it has at the time.Escitalopram may be superior in efficacy compared with other SSRIs in the treatment of major depressive disorder While SSRIs do not appear to differ in overall tolerability, the reported incidences of specific side effects vary.Antidepressants have some different pharmacological characteristics, this means that patients may respond differently to certain SSRIs or experience different side effects with different drugs.The SSRIs represent the first rationally designed class of psychotropic medications.The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (e.g., uptake pumps, receptors) while avoiding effects on other site of actions.

Each SSRI has a unique profile of multiple pharmacologic actions, which explains the differences in their efficacy and tolerabilitythe most potent serotonin reuptake blocker, but has a low selectivity for the serotonin reuptake muscarinic cholinergic receptors (most potent blocker of muscarinic receptors among the SSRIs) histamine H1 receptors nitric oxide synthase cytochrome P450 2D6 the second most potent inhibitor of serotonin reuptake and the second most selective blocker of serotonin over noradrenaline uptake dopamine reuptake (more potent dopamine uptake inhibitor than other SSRIs) All the SSRIs are licensed for major depressive disorder and are considered to be the first-line treatments of depression.Low levels of serotonin and norepinephrine have not been proven to cause depression but it is widely believed that elevation of these chemicals is associated with improvement in mood in depressed people.All selective serotonin reuptake inhibitors have the same principal mechanism of action.SSRIs seem to relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain.This leaves more serotonin available, which enhances neurotransmission and improves mood.

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